Platelet Survival Time In Men With Post Myocardial Infarction And Normal Coronary Arteriogram
Thrombosis and Haemostasis
Some patients fail to show any evidence of arte riographic coronary obstruction following an episode of myocardial infarction. This type of subjects would all present a shortened mean platelet survival.Over a year's period, platelet survival time (Chromium 51 labelling)was measured in 8 subjects who, one month after suffering an acute transmural infarction, were found to have a normal coronary arteriogram (NC). Survival times were determined between 3 and 12 months after the infarction. At this
... infarction. At this moment, all the patients were asymptomatic.As control, and simultaneously, platelet survival time was evaluated at random in 8 patients who had had a myocardial infarction with arteriographic evidence of coronary obstruction (AC), and in 11 normal subjects (NS).Platelet life span was measured by fitting the gamma fonction at 11 days of survival experimental points and the goodness of fitting surveyed by a graphic terminal (Tektroniks 4051). Since a failure of fitting with this system was found in 30% of cases, the mean weight method of computting platelet life span had to be employed.The results of the mean platelet survival time in the three groups of individuals show no significant differences : NS 7,76 ± 0,89; NC 7,48 ±1,68 AC 7,64 ± 0,87 (days ± 1 SD). Only two patients with normal coronary arteriogram had values lower than the inferior range of normal subjects.These results do not agree with others.