ORIGINAL ARTICLES Effect of Moringa Oleifera on serum lipids and kidney function of hyperlipidemic rats

Mona Halaby, Mona Halaby, Eman Elmetwaly, Aya Omar
2013 Journal of Applied Sciences Research   unpublished
The present work aims to study the potential effect of fortified bread with Moringa Oleiferato (MO) leaves powder under 5%, 10% & 15% concentrations to give more protection against hyperlipidemia .Thirty-two male albino rats were used in this experiment. These rats were put on ideal diet for two weeks before the performance of experiment. At the beginning, these rats were divided into four main groups and fed on diets for 45 days as follows: The first group fed on basal diet as a negative
more » ... as a negative control. The second group fed on high fat diet (2% cholesterol) to induce hyperlipidemia as a positive control. The third and fourth groups fed on high fat diet containing fortified bread with 10% & 15% (MO) powder. At the end of the experimental period, blood samples were collected from the aorta to determine serum lipids and determine the kidney functions include serum uric acid, urea nitrogen and creatinine. Also, the kidney and heart were removed surgically for histopathological observation. From the obtained results we concluded that group of rats fed on high fat diet were considered as a major risk factor for hyperlipidemia disease. Our results could be summarized that bread fortified with MO at 10% & 15% were considered the best for causing a reduction of TC, TG, LDL and VLDL. Also, kidney function has been improved and there were significant reduction in uric acid serum, urea, and creatinine than that of positive control group. In fact, feeding bread fortified with MO improved the body weight gain and food intake. Histopathological observation proved that the last group diet is considered as a negative control group. We can conclude that fortified diet with 15% MO level powder realized the best effects on hyperlipidemia rats.