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Electrical signatures of single-stranded DNA with single base mutations in a nanopore capacitor
In this paper, we evaluate the magnitude of the electrical signals produced by DNA translocation through a 1 nm diameter nanopore in a capacitor membrane with a numerical multi-scale approach, and assess the possibility of resolving individual nucleotides as well as their types in the absence of conformational disorder. We show that the maximum recorded voltage caused by the DNA translocation is about 35 mV, while the maximum voltage signal due to the DNA backbone is about 30 mV, and thedoi:10.1088/0957-4484/17/13/014 fatcat:sxmegsekufao7kq5c27ubbo63y