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Loss of Parkin impairs mitochondrial function and leads to muscle atrophy
2018
American Journal of Physiology - Cell Physiology
son's disease is a neurodegenerative disease characterized by tremors, muscle stiffness, and muscle weakness. Molecular genetic analysis has confirmed that mutations in PARKIN and PINK1 genes, which play major roles in mitochondrial quality control and mitophagy, are frequently associated with Parkinson's disease. PARKIN is an E3 ubiquitin ligase that translocates to mitochondria during loss of mitochondrial membrane potential to increase mitophagy. Although muscle dysfunction is noted in
doi:10.1152/ajpcell.00064.2017
pmid:29561660
fatcat:tz7shxoruvfhxlgzau63vebewa