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Extracellular adenosine signaling reverses the age-driven decline in the ability of neutrophils to kill S. pneumoniae
[article]
2020
bioRxiv
pre-print
SummaryThe elderly are susceptible to serious infections by Streptococcus pneumoniae (pneumococcus), which calls for a better understanding of the pathways driving the decline in host defense in aging. We previously found that extracellular adenosine (EAD) shaped polymorphonuclear cell (PMN) responses, which are crucial for controlling infection. EAD is produced by CD39 and CD73, and signals via A1, A2A, A2B and A3 receptors. The objective of this study was to explore the age-driven changes in
doi:10.1101/2020.04.14.041418
fatcat:i7cgplarhfdslhbl44dzrpyxlu