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Insulin resistance is the main target in preventing accelerating arterial aging
2013
Artery Research
Objectives: Autosomal dominant polycystic kidney disease (ADPKD) is due to mutations in genes PKD1 and PKD2 encoding polycystin-1 and -2, which transduce flow variations into cellular signals in the renal epithelium but also in vascular endothelium. However, the impact of polycystin deficiency on the release of endothelium-derived factors during flow variations is unknown. Methods: In 21 normotensive ADPKD patients with normal kidney function and 21 control subjects, radial artery diameter and
doi:10.1016/j.artres.2013.10.127
fatcat:qhrfiru2x5d4xiebr27hx35gcu