Clopidogrel-induced Acute Interstitial Pneumonitis: a Case Report [post]

Jin An, Seung Hwan Lee, Boksoon Chang
2021 unpublished
Background In patients with cerebral infarction resulting from intracranial arterial stenosis, combined administration of clopidogrel and aspirin may be needed for the thereafter ischemic attack. Clopidogrel has an inevitable adverse effect profile, and the most common complications are related to hemorrhagic propensity. Case presentation A 79-year-old female patient had taken aspirin (100mg/d) for old cerebral infarction, and started taking the dual antiplatelet drug consisted of aspirin and
more » ... ed of aspirin and clopidogrel (75mg/d) due to severe stenosis on both anterior cerebral arteries. Two weeks later, the patient presented dyspnea started 3 days ago, which had been worsened the last 24 h. Chest computed tomography on admission showed symmetric peribronchial ground glass opacity with reticulation in both lungs. Microorganism tests, including serology and bronchoalveolar lavage for infection, were all negative. Suspecting clopidogrel-induced acute interstitial pneumonitis, we withdrew clopidogrel and initiated steroid treatment. The patient's clinical signs and chest radiographs improved after steroid treatment, and she was discharged on the 21st day of hospitalization. Conclusions Clopidogrel can induce acute interstitial pneumonitis as a rare complication. The present report shows the importance of recognizing this rare adverse effect of clopidogrel in clinical practice.
doi:10.21203/ fatcat:yz7g3ub6ifeh3ojcorbpcdqwjm