Sept. 2o, I873.] THE BRITISH MEDICAL 7OURNAL. 345 once brought together by the suture. By this means, not more than sixty or eighty seconds passed between the separation of the tumour and its inoculation. The diagnosis of epitbelioma was in all cases confirmed by the microscope. I do not speak here of observations upon other malignant growths which I have made. EXPERIMENT I.-July Ist, I87I. A black and white guinea-pig was inoculated with epithelioma of the penis into the left flank, and also a

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... black tan and white guinea-pig with the same material into the peritoneum. These animals were killed at Christmas I87I ; but nothing unnatural could be discovered on examining their bodies. No tuberculosis was found. EXPERIMENT II. August gth, I87I. I inoculated a black and tan guinea-pig with epithelioma of the scrotum. It was found dead on October igth. It was examined; but no new growths were discovered, or, indeed, any cause of death. EXPERIMENT iII.-Novembr 8th, 1871I. A guinea-pig was inoculated with epithelioma of the uterus into the left flank. EXPERIMENT iV. November 22nd, I87I. Two white rats, aged three months, were inoculated with epithelioma of the tongue-one under the skin of the rump, the other into the peritoneum. EXPERIMENT v. -January 6th, I872. A piebald rat was inoculated -under the skin of the flank. The animals in these last three experiments were all killed and examined on May ioth, I872. There were no discoverable lesions or new growths. It may be well to state that the places of inoculation, beyond the scar of the cut, showed a perfectly natural appearance. During the first few weeks that followed the inoculation, a hardness could generally be felt around the place; but, at the time of death, it always presented a perfectly natural appearance. No tuberculosis,