Age: The Most Important Risk Factor for Cervical Stenosis and Cervical Intraepithelial Neoplasia Recurrence After Cervical Conization

Yoichi Aoki
2018 Journal of Gynecology and Womens Health  
Patients and Methods Data on 370 patients with CIN3, adenocarcinoma in situ (AIS), or atypical glandular cells treated with only laser conization between 2010 and 2016 at the University of the Ryukyus Hospital were collected. The patients' clinicopathological data Abstract Background: To evaluate the incidence of cervical stenosis and rate of recurrence after laser conization and to identify risk factors for these conditions. Methods: Data on 370 patients with CIN3, or AIS treated with only
more » ... eated with only laser conization between 2010 and 2016 at our Hospital were collected. Multivariate analyses were used to evaluate associations between clinical variables and postoperative cervical stenosis or CIN recurrence. Results: The median age was 43 (range, 27-89) years and follow-up period was 27 (range, 1-103) months. Cervical stenosis was diagnosed in 37 patients (10.0%), with CIN recurrence in 21 patients (5.7%). The multivariate analysis identified age (≥44 years) and parity as significant risk factors for cervical stenosis and revealed that positive surgical margins, smoking, and age (≥44 years) were significant risk factors for CIN recurrence. Only patient age (≥44 years) was a significant risk factor for both cervical stenosis and CIN recurrence. Furthermore, patients aged ≥44 years and with positive surgical margins exhibited a significantly higher rate of CIN recurrence and significantly shorter CIN-free period than those with negative surgical margins. Conclusion: Other surgical options such as subsequent hysterectomy may be considered and can be beneficial for such elderly patients.
doi:10.19080/jgwh.2018.12.555845 fatcat:tkmdey3gzrgr7deef34pkqbp7u