Myoid Gonadal Stromal Tumor

Chia-Sui Kao, Thomas M. Ulbright
2014 American Journal of Clinical Pathology  
Objectives: To report three new cases of testicular myoid gonadal stromal tumor to better characterize its features. Methods: The clinicopathologic findings (including follow-up) were evaluated and a review of the literature was performed. Results: The patients were 38, 43, and 59 years old, and tumor sizes were 1.2, 1.3, and 3.2 cm. All were unilateral, well circumscribed, adjacent to the rete testis, and composed exclusively of spindled cells with elongated nuclei and occasional nuclear
more » ... ional nuclear grooves arranged in fascicles with admixed variably ectatic blood vessels. Nucleoli were inconspicuous, and the cytoplasm was scant, ill-defined, and pale/lightly eosinophilic. No sex cord component was present. Mitotic figures ranged from zero to five per 10 high-power fields. Significant atypia, lymphovascular invasion, and necrosis were absent. All were consistently positive for smooth muscle actin, S100 protein, FOXL2, and steroidogenic factor 1 but negative for h-caldesmon, calretinin, and SOX9. Inhibin and calponin were focally positive. All patients were alive and well at 5, 31, and 58 months postorchiectomy. Combining our cases with those previously reported (n = 6) shows that this neoplasm occurs mostly in younger men (mean, 37 years), and all follow-up thus far (mean, 25 months) has been benign.
doi:10.1309/ajcpgscd1dgnz0qo pmid:25319984 fatcat:ndhf3rkijjdj5odvo7vwrfqmjq