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Numerous neurotransmitter systems [e.g. dopamine, y-aminobutyric acid (GABA), the endogenous opioids, and serotonin (5-hydroxytryptamine, 5-HT)] are involved in the regulation of alcohol consumption. Because 5-HT reuptalce inhibitors and opioid antagonists modify the activity of neurotransmitters, it has been hypothesized that they may also mediate the desire to drink alcohol by acting on specific receptors in the brain. Animal studies have shown that concomitant administration of 5-HT anddoi:10.1093/oxfordjournals.alcalc.a008215 fatcat:qhwiv452erddjic3lzfvgemsja