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Transforming growth factor β1 (TGFB1) is increased in the lungs of asthmatics and may modulate airway inflammation and remodeling. Some genetic studies have found that a C to T single nucleotide polymorphism (C-509T) in the TGFB1 gene promoter may be associated with altered gene expression and asthma phenotype. To build on these data, we performed a casecontrol association study at this locus involving 527 asthmatics and 170 controls without asthma. All individuals were Caucasians. Genotypingdoi:10.1164/rccm.200307-973oc pmid:14597484 fatcat:6yskty3q4jauhp3ugwfhuotmku