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Heterotrimeric G-protein Signaling Is Critical to Pathogenic Processes in Entamoeba histolytica
2012
PLoS Pathogens
Heterotrimeric G-protein signaling pathways are vital components of physiology, and many are amenable to pharmacologic manipulation. Here, we identify functional heterotrimeric G-protein subunits in Entamoeba histolytica, the causative agent of amoebic colitis. The E. histolytica Ga subunit EhGa1 exhibits conventional nucleotide cycling properties and is seen to interact with EhGbc dimers and a candidate effector, EhRGS-RhoGEF, in typical, nucleotide-stateselective fashions. In contrast, a
doi:10.1371/journal.ppat.1003040
pmid:23166501
pmcid:PMC3499586
fatcat:oxczrqtipvc43ch2sh6bj4ev2e