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Loss of IFN Receptor Is an Independent Prognostic Factor in Ovarian Cancer
Clinical Cancer Research
Purpose: There is evidence that IFNg plays an important role in ovarian cancer development. IFNg produces numerous antitumor effects and it may be evasion of these effects which allows tumor progression. We postulate that genetic instability in tumor cells may lead to modulation of expression of the IFNg receptor, thus leading to altered tumor biology and patient prognosis.This hypothesis would support the theory of immunoediting in ovarian cancer. Experimental Design: Using tissue microarraydoi:10.1158/1078-0432.ccr-06-2833 pmid:17634541 fatcat:uvtkv6it5bfq7ms3rpjosxwhdy