Synthesis of Quinoline Derivatives Containing Lactone Structure Promoted by Radical Cation Salt

Xuewen Zhang, Pengfei Li, Yu Yuan, Xiaodong Jia
2018 Youji huaxue  
Using aniline derivatives containing lactone structure and styrenes as the starting materials, a series of lactone substituted quinolines were constructed efficiently by oxidative Povarov reaction, promoted by radical cation salt. This reaction provides a new method to achieve the construction of functionalized quinoline skeletons. The mechanistic study reveales that the oxidation of the saturated C-H bond is mediated by free radical intermediate.
doi:10.6023/cjoc201804012 fatcat:zqo443xinndv5ixkoftbi5mcbi