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Deciphering the tissue-specific regulatory role of intronless genes across cancers
[article]
2022
bioRxiv
pre-print
Intronless genes (IGs) or single-exon genes lacking an intron are found across most Eukaryotes. Notably, IGs display a higher transcriptional fidelity as they are not regulated through alternative splicing, suggesting better predictability biomarkers and easier regulation as targets for therapy. Cancer is a complex disease that relies on progressive uncontrolled cell division linked with multiple dysfunctional biological processes. Tumor heterogeneity remains the most challenging feature in
doi:10.1101/2022.02.21.481319
fatcat:6znbtjgxxzf5dgk7lllbcgrfym