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Enhancement of human immunodeficiency virus type 1 infectivity by Nef is producer cell-dependent
1998
Journal of General Virology
Preserved Fulltext
The growth kinetics of wild-type and nef mutant viruses of human immunodeficiency virus type 1 were comparatively analysed in several human CD4 M cell lines. Delayed replication of nef mutant virus was observed in all cell lines examined. To determine the stage in the virus replication cycle that is affected by Nef, a single-round replication assay was performed. Initially, the expression of marker genes in transfected cells was examined in order to study the role of Nef in the late phase of
doi:10.1099/0022-1317-79-10-2447
pmid:9780050
fatcat:esofxtxyynb65oytjxno4mjuda