Transgenic Animal Models in Toxicology: Historical Perspectives and Future Outlook

Darrell R. Boverhof, Mark P Chamberlain, Clifford R. Elcombe, Frank J. Gonzalez, Robert H. Heflich, Lya G. Hernández, Abigail C. Jacobs, David Jacobson-Kram, Mirjam Luijten, Adriana Maggi, Mugimane G. Manjanatha, Jan van Benthem (+1 others)
2011 Toxicological Sciences  
FIG. 2. The outcome of a Cre-lox recombination is determined by the orientation and location of flanking loxP sites. (A) If the loxP sites are oriented in opposite directions, Cre recombinase mediates the inversion of the floxed segment. (B) If the loxP sites are located on different chromosomes (trans arrangement), Cre recombinase mediates a chromosomal translocation. (C) If the loxP sites are oriented in the same direction on a chromosome segment (cis arrangement), Cre recombinase mediates a
more » ... eletion of the floxed segment. (By J. Pendola in http://jaxmice.jax.org). TRANSGENIC ANIMAL MODELS IN TOXICOLOGY 209 Downloaded from https://academic.oup.com/toxsci/article-abstract/121/2/
doi:10.1093/toxsci/kfr075 pmid:21447610 fatcat:esy25m3apfej7h46h6wcelevpy