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Using systems biology to simplify complex disease: Immune cartography
2009
Critical Care Medicine
What if there was a rapid, inexpensive, and accurate blood diagnostic that could determine which patients were infected, identify the organism(s) responsible, and identify patients who were not responding to therapy? We hypothesized that systems analysis of the transcriptional activity of circulating immune effector cells could be used to identify conserved elements in the host response to systemic inflammation, and furthermore, to discriminate between sterile and infectious etiologies. We
doi:10.1097/ccm.0b013e3181920cb0
pmid:19104218
pmcid:PMC4077162
fatcat:u4pyxsq7vzd77le3kcldqzvk54