Incidence of Adverse Drug Reactions in First Line Antiretroviral and Antitubercular Drugs

Chaitali Yadav, Pandharinath Thorat, Amitkumar Khade
2015 Human Journals Review Article May   unpublished
Worldwide, TB is the most common co-infection in subjects infected with HIV-1. The high mortality risk of patients with HIV-associated tuberculosis (TB) is reduced by 64% to 95% by antiretroviral therapy (ART). The authors reviewed the literature for adverse drug reactions of five first line antituberculous medications (isoniazid, rifampin, pyrazinamide, ethambutol and streptomycin). Some ARVs have drug interactions with ATT, therefore appropriate drug choices become imperative. NRTIs like
more » ... udine (AZT), Didanosine (ddI), Stavudine (d4t), Lamivudine (3TC) and Abacavir can be safely co-administered with anti-TB drugs.