This paper reports on new agile approaches and methods for design modelling of collaborative networked enterprises, ranging from small manufacturing supply-chains to major public service organizations. Use-cases in selected fields have been implemented by agile modelling and holistic design of collaborative networking capabilities, and active knowledge architecture driven solutions. The active knowledge architecture is the knowledge base for collaborative planning, execution, validation,

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... ment and reuse. Use-case projects are transformed from horizontally sliced, sequential activities supported by information flows to collaborative workspaces and knowledgedriven processes. Novel concepts, agile approaches, adaptive methods, open platforms, and emergent knowledge architecture-driven solutions are built and validated. The realization of agile workplaces and sustainable capabilities for collaborative networking open up for novel approaches to computing solutions. Use-case digital models to enhance human mental models and enable collaborative innovation and learning and competence transfer are implemented.