ALE meta-analysis workflows via the BrainMap database: Progress towards a probabilistic functional brain atlas

Angela R. Laird
2009 Frontiers in Neuroinformatics  
With the ever-increasing number of studies in human functional brain mapping, an abundance of data has been generated that is ready to be synthesized and modeled on a large scale. The BrainMap database archives peak coordinates from published neuroimaging studies, along with the corresponding metadata that summarize the experimental design. BrainMap was designed to facilitate quantitative meta-analysis of neuroimaging results reported in the literature and supports the use of the activation
more » ... lihood estimation (ALE) method. In this paper, we present a discussion of the potential analyses that are possible using the BrainMap database and coordinate-based ALE meta-analyses, along with some examples of how these tools can be applied to create a probabilistic atlas and ontological system of describing function-structure correspondences.
doi:10.3389/neuro.11.023.2009 pmid:19636392 pmcid:PMC2715269 fatcat:ycjscysglncfzkrue2oybvrz3u