Studying Molecular Aspects of the Blood-Brain Barrier Using an in Vitro Model: Contribution of a Global Proteomics Strategy

Yannis Karamanos
2014 Journal of Biosciences and Medicines  
A global proteomics strategy was initiated to decipher molecular mechanisms associated with the blood-brain barrier (BBB) phenotype of the brain capillary endothelial cells. The different methods implemented were shown complementarily. The main results obtained using an in vitro BBB model allowed highlighting the role of several protein actors of cytoskeleton remodelling, the involvement of the asymmetric dimethylarginine pathway in regulating endothelial function and the role of tissue
more » ... e of tissue non-specific alkaline phosphatase in the regulation of endothelial permeability.
doi:10.4236/jbm.2014.21003 fatcat:gmxh2l6kbnbjdda4vmflyd3idm