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Multi-Omics Binary Integration via Lasso Ensembles (MOBILE) for identification of context-specific networks and new regulatory mechanisms
[article]
2022
bioRxiv
pre-print
Cell phenotypes are dictated by both extra- and intra-cellular contexts, and robust identification of context-specific network features that control phenotypes remains challenging. Here, we developed a multi-omics data integration strategy called MOBILE (Multi-Omics Binary Integration via Lasso Ensembles) to nominate molecular features associated with specific cellular phenotypes. We applied this method to chromatin accessibility, mRNA, protein, and phospho-protein time course datasets and
doi:10.1101/2022.07.24.501297
fatcat:fnhisotqbnahhecph4iqcottfa