Vitamins (A, B 1 and C) status of Nigerians with Trypanosoma brucei gambiense-infection

Isaac, Nmorsi, Igbinosa, Umukoro
2010 Reviews in Infection RIF RIF   unpublished
Vitamins A, B 1 and C profiles were evaluated among 35 Trypanosoma brucei gambiense seropositive volunteers. Of the 35 seropositives, 9 were weakly positive, 12 had moderate positivity and strongly positive infection occurred among 14 of them. Parasites were detected in the cerebrospinal fluid (CSF) of 4 volunteers with strong positive titre (≥1:32). In the blood/serum, the prevalence of the T. b. gambiense were 4 for weakly positive, 5 for moderately positive and 7 for strongly positive
more » ... gly positive volunteers. The mean vitamin A concentrations between the control subjects (7.77±6.99 nmol/L) and the seropositive volunteers were statistically significant (p<0.05). Vitamin B 1 levels were significantly depressed in the strongly positives (8.26±1.85 nmol/L) and the moderately positives (16.7±2.66 nmol/L) when compared with the control subjects (38.26±1.58 nmol/L) (χ 2 =23.49, p<0.05 and χ 2 =12.14, p<0.05), respectively. The differences in vitamin C concentrations in the control subjects and the infected volunteers were not statistically significant at χ 2 =0.58, p>0.05; χ 2 =3.36, p>0.05 and χ 2 =0.94, p>0.05 for weakly, moderately and strongly positive, respectively. We therefore conclude that the depressed vitamins A and B 1 concentrations may be implicated in the pathogenesis of T.b. gambiense infection.