miRNA-199a/214 Cluster Enhances Fibrosis of Human Peritoneal Mesothelial Cells Regulated by SRF

Lijie He, Shiren Sun, Hanmin Wang, Jinping Hu, Tiantian Shi
2015 Hong Kong Journal of Nephrology  
Results: The average BDI score and PSQI score of the CAPD patients were 12.1 AE 7.9 and 6.6 AE 4.0, with 23(40.4%) depressed patients (BDI score > OR Z 16) and 37 (64.9%) poor sleepers (PSQI scores > OR Z 5). In univariate analysis, the BDI score was positively correlated with serum b2 microglobulin (r Z 0.255, P Z 0.011) and Peritoneal Kt/Vurea (r Z 6.289, P Z 0.038), While the PSQI score was negatively correlated with serum albumin (r Z À0.333, P Z 0.007) and positively correlated with
more » ... nsitivity C-reactive protein (r Z 0.014, P Z 0.016), duration on CAPD (r Z 0.084, P Z 0.009), serum creatinine (r Z 0.005, P Z 0.013), serum phosphate (r Z 2.186, P Z 0.034), serum b2 microglobulin (r Z 0.184, P < 0.01) and Peritoneal Kt/Vurea (r Z 3.409, P Z 0.018). In multiple analysis, high serum b2 microglobulin (b Z 0.301, P Z 0.010) was the independent predictor of depression in CAPD patients, and long duration on CAPD (b Z 0.129, P Z 0.003) was the only risk factor for sleep disturbance in CAPD patients. Conclusion: Depression and sleep disturbance are common in Chinese CAPD patients. Close relationships exist between serum b2 microglobulin and depression, duration on CAPD and poor sleep quality. http://dx.
doi:10.1016/j.hkjn.2015.09.179 fatcat:mxtrwsojnzbgxcgpmbmsltq7ke