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The serotonin reuptake inhibitor Fluoxetine inhibits SARS-CoV-2 in human lung tissue
AbstractTo circumvent time-consuming clinical trials, testing whether existing drugs are effective inhibitors of SARS-CoV-2, has led to the discovery of Remdesivir. We decided to follow this path and screened approved medications "off-label" against SARS-CoV-2. Fluoxetine inhibited SARS-CoV-2 at a concentration of 0.8 µg/ml significantly in these screenings, and the EC50 was determined with 387 ng/ml. Furthermore, Fluoxetine reduced viral infectivity in precision-cut human lung slices showingdoi:10.1038/s41598-021-85049-0 pmid:33723270 fatcat:p2w4lfhl3vcnfj7fxpgpsokani