Objective To investigate the influence of adefovir dipivoxil (ADV) versus telbivudine (LdT) combined with entecavir (ETV) on liver function and serum virology of hepatitis B patients with decompensated liver cirrhosis (DLC). Methods Eighty DLC patients in our hospital from February 2014 to April 2015 were selected and divided into two groups (40 in each group). Observation group was given LdT combined with ETV, control group was given ADV. The liver function and serum virology were observed 12,

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... 24, 48 weeks after treatment in the two groups. Results Before treatment, the expression level and Child-pugh score between observation group [ALT(156.3±50.2)U/L, ALB (30.5±3.8)g/L, TBil (60.4±23.1)µmol/L, PTA (40.3%±7.8%), and Child-pugh score (11.3±1.5) points] and control group [ALT (154.1±51.4)U/L, ALB (31.3±4.2)g/L, TBil (58.9±24.3)µmol/L, PTA (42.1%±8.4%), and the score (11.2±2.0) points] were compared with no statistically significant difference between the two groups (P>0.05); after a period of treatment, ALT, TBil and Child-pugh score decreased gradually, while ALB and PTA increased gradually in the two groups, and the difference was statistically significant compared to the pretreatment (P<0.05). With the passage of time, ALT, TBil and Child-Pugh score were lower, while ALB and PTA higher in the observation group than in control group, and the difference was statistically significant (P<0.05). At the same period after treatment, the negative conversion rates of HBV-DNA and HBeAg were obviously higher in the observation group than in the control group (P<0.05). Conclusion LDT combined with ETV in treating decompensated hepatitic cirrhosis has better effect than ADV does. Liver function recovered quicker, negative conversion ratio is higher, adverse reaction is less and LDT plus ETV is worthy of wide application. DOI: 10.11855/j.issn.0577-7402.2016.12.14