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Application of the matched nested case-control design to the secondary analysis of trial data
A matched nested case-control design provides an efficient way to investigate causal relationships using untapped data from prospective cohort studies and randomised controlled trials This method has several advantages over a standard case-control design, particularly when studying time-dependent exposures on rare outcomes It offers the potential to make reliable inferences in scenarios where unethical or practical issues preclude the use of a randomised controlled trialdoi:10.21203/rs.2.18727/v1 fatcat:huv4ngorafdqra4cei7w6umg4a