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Clusterin (APOJ) in Alzheimer's Disease: An Old Molecule with a New Role
Update on Dementia
Clusterin (CLU), initially identified in 1983 as a "clustering factor" in ram rete testis fluid, is a multifaceted protein that was re-discovered and subsequently renamed eight times from 1983 to 1992. CLU exists as multiple protein isoforms including the 80 kDa glycosylated mature/secreted form of CLU (mCLU) and the smaller non-modified nuclear and intracellular forms of CLU (nCLU and icCLU, respectively). These isoforms, which are expressed at the highest levels in the brain, are suggested todoi:10.5772/64233 fatcat:5ifhxp54njfmtgxvknkp75rate