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VarDict: a novel and versatile variant caller for next-generation sequencing in cancer research
2016
Nucleic Acids Research
Accurate variant calling in next generation sequencing (NGS) is critical to understand cancer genomes better. Here we present VarDict, a novel and versatile variant caller for both DNA-and RNA-sequencing data. VarDict simultaneously calls SNV, MNV, InDels, complex and structural variants, expanding the detected genetic driver landscape of tumors. It performs local realignments on the fly for more accurate allele frequency estimation. VarDict performance scales linearly to sequencing depth,
doi:10.1093/nar/gkw227
pmid:27060149
pmcid:PMC4914105
fatcat:46uid6xw7zeinfmjavuahb55ta