CORRELATION OF MALONDIALDEHYDE AND ANTIOXIDANTS OF SERUM IN THE HORSES WITH STRANGLES

Ali Hassanpour
2013 Indian Journal of Fundamental and Applied Life Sciences   unpublished
This study was conducted on horses with strangles for evaluation of correlation between serum concentration of malondialdehyde (MDA) as an oxidative marker and serum antioxidants (Glutathione Peroxidase (GPx), Superoxide Dismutase (SOD), Catalase (CAT), Total Antioxidant Capacity (TAC), Vitamin E (Vit E), Vitamin C (Vit C) and Selenium (se)) and Hemoglobin (HB). 10 horses confirmed on the bases of clinical and laboratory signs of strangles. Blood samples tacked from jugular vein and separated
more » ... ein and separated serum. Sampling performed from 8 healthy horses, too. Serum concentrations of MDA, HB, Vit E, Vit C, Se, TAC and serum's activity of GPx, SOD and CAT enzymes measured in the samples. There was a negative correlation between MDA and serum's antioxidants in two groups, which antioxidants decreased in the serum with increasing of MDA. The correlation between MDA with GPx, SOD, CAT, TAC, Vit E, Se and HB was significant in the patient group (p<0.05) (r=-0.954, r=-0.876, r=-0.890, r=-0.745, r=-0.684 and r= 0.945, respectively) and was not significant with Vit C. In the healthy group these correlations were significant in SOD, CAT, TAC and HB (p<0.05) (r=-0.817, r=-0.914, r=-0.749 and r=0.756, respectively), but nonsignificant in GPx, Vit E, Vit C and Se. In conclusion, there was an oxidative stress in the horses with strangles and oxidants use in compare antioxdant markers in the serum and this result must be observe in treatment them.
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