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The biological pathways involved in the preclinical stage of the Alzheimer's continuum are not well understood. We used NeuroToolKit and Elecsys® immunoassays to measure cerebrospinal fluid (CSF) amyloid-β (Aβ)42, Aβ40, phosphorylated tau (p-tau), total tau (t-tau), neurofilament light (NfL), neurogranin, sTREM2, YKL40, GFAP, IL6, S100, and α-synuclein in cognitively unimpaired participants of the ALFA+ study, many within the Alzheimer's continuum. CSF t-tau, p-tau, and neurogranin increasedoi:10.1002/alz.12131 pmid:32573951 fatcat:hclihedpovevfd7lxv27uj7xiq