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Ca 2ϩ channel inactivation is a key element in controlling the level of Ca 2ϩ entry through voltage-gated Ca 2ϩ channels. Interaction between the pore-forming ␣ 1 subunit and the auxiliary ␤ subunit is known to be a strong modulator of voltage-dependent inactivation. Here, we demonstrate that an N-terminal membrane anchoring site (MAS) of the ␤ 2a subunit strongly reduces ␣ 1A (Ca V 2.1) Ca 2ϩ channel inactivation. This effect can be mimicked by the addition of a transmembrane segment to the Ndoi:10.1523/jneurosci.20-24-09046.2000 pmid:11124981 fatcat:vkhn7xihkngqzj3acwbbbu3cvu