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PO-0668: Tumor volume as an essential prognostic factor for radiotherapy outcome in patients with early laryngeal cancer
Radiotherapy and Oncology
2nd ESTRO Forum 2013 S253 Purpose/Objective: Nuclear EGFR has been implicated in resistance to both radiation and EGFR-inhibition. Src family kinases (SFKs) are required for translocation of EGFR to the nucleus. We investigated whether inhibition of SFK via dasatinib can enhance the effect of radiotherapy in in vivo head and neck squamous cell carcinoma (HNSCC) models. Materials and Methods: Two HNSCC xenograft models, SCCNij153 and SCCNij202, were treated with dasatinib, radiation or both, anddoi:10.1016/s0167-8140(15)32974-1 fatcat:yxvwlvmm5zebhdwppwzesafgmy