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Off-label tocilizumab use in COVID-19 patients reflects concern for cytokine release syndrome. Comparison of matched COVID-19 pneumonia patients found elevated IL-6 levels correlated with mortality that did not change with tocilizumab administration. Correlating mortality with increased IL-6 doesn't imply causality however lack of improvement by tocilizumab requires clinical trial alterations.doi:10.21203/rs.3.rs-39875/v1 fatcat:dklxtsesvnfstmjbovs25juvue