Addressing the challenges of multiscale model management in systems biology

J. Hetherington, I.D.L. Bogle, P. Saffrey, O. Margoninski, L. Li, M. Varela Rey, S. Yamaji, S. Baigent, J. Ashmore, K. Page, R.M. Seymour, A. Finkelstein (+1 others)
2007 Computers and Chemical Engineering  
stract athematical and computational modelling are emerging as important techniques for studying the behaviour of complex biological systems. argue that two advances are necessary to properly leverage these techniques: firstly, the ability to integrate models developed and executed on arate tools, without the need for substantial translation and secondly, a comprehensive system for storing and man-ageing not only the models mselves but also the parameters and tools used to execute those models
more » ... nd the results they produce. A framework for modelling with these tures is described here. We have developed of a suite of XML-based services used for the storing and analysis of models, model parameters results, and tools for model integration. We present these here, and evaluate their effectiveness using a worked example based on part of the atocyte glycogenolysis system.
doi:10.1016/j.compchemeng.2006.10.004 fatcat:4gcrr4jr3ncobgfaraeuuqcuve