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Amplitude and Kinetics of Action Potential-Evoked Ca2+ Current and Its Efficacy in Triggering Transmitter Release at the Developing Calyx of Held Synapse
Journal of Neuroscience
Action potentials (APs) play a crucial role in evoking Ca 2ϩ currents (I Ca ) through voltage-gated calcium channels (VGCCs) and transmitter release. During development and neuromodulation, both depolarization and repolarization phases of APs change, but how such changes affect the characteristics of I Ca and its efficacy at central synapses is not clear. By paired voltage-clamp recordings of I Ca and excitatory postsynaptic currents (I EPSC ) with pseudo-APs and real APs, we examined thesedoi:10.1523/jneurosci.4889-05.2006 pmid:16723526 fatcat:cbyxsbkciraunfs5psookzahem