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Genetic Targeting of Green Fluorescent Protein to Gonadotropin-Releasing Hormone Neurons: Characterization of Whole-Cell Electrophysiological Properties and Morphology
2000
Endocrinology
GnRH neurons form the final common pathway for central control of reproduction, with regulation achieved by changing the pattern of GnRH pulses. To help elucidate the neurobiological mechanisms underlying pulsatile GnRH release, we generated transgenic mice in which the green fluorescent protein (GFP) reporter was genetically targeted to GnRH neurons. The expression of GFP allowed identification of 84 -94% of immunofluorescently-detected GnRH neurons. Conversely, over 99.5% of GFP-expressing
doi:10.1210/en.141.1.412
pmid:10614664
fatcat:n544peaafbbgtp3usrvjhq3jeu