Diagnostic and prognostic value of serum interleukin-16 in patients with gastric cancer

Hongyun Yang, Yanyan Han, Lele Wu, Chaojun Wu
2017 Molecular Medicine Reports  
Gastric cancer (GC) is one of the major leading causes of cancer-associated mortality worldwide. Serum biomarkers have a vital role in diagnosis and prognosis of GC, and interleukin (IL)-16 may serve as a useful biomarker with prognostic value for human cancers. The current study aimed to evaluate the expression level of serum IL-16 in patients with GC, and evaluate the diagnostic and prognostic value of IL-16. ELISA was performed determine the serum IL-16 levels in patients with GC and healthy
more » ... with GC and healthy controls. Receiver operator curve analysis was performed to evaluate the diagnostic and prognostic potential value of serum IL-16 in GC diagnosis. Migration and invasion assays were performed using cells with IL-16 small interfering RNA (siRNA) knockdown. The results demonstrated that serum IL-16 levels were significantly higher in GC samples than in healthy controls, and increased serum IL-16 levels were significantly associated with tumor recurrence and poor prognosis. Knockdown of IL-16 significantly suppressed the migration and invasion of GC cells. In conclusion, the current results indicate that serum IL-16 levels may have diagnostic and prognostic value for patient with GC.
doi:10.3892/mmr.2017.7688 pmid:28990054 fatcat:hv57zgbzrbbhhd44hqpkjosy2q