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Gastric cancer (GC) is one of the major leading causes of cancer-associated mortality worldwide. Serum biomarkers have a vital role in diagnosis and prognosis of GC, and interleukin (IL)-16 may serve as a useful biomarker with prognostic value for human cancers. The current study aimed to evaluate the expression level of serum IL-16 in patients with GC, and evaluate the diagnostic and prognostic value of IL-16. ELISA was performed determine the serum IL-16 levels in patients with GC and healthydoi:10.3892/mmr.2017.7688 pmid:28990054 fatcat:hv57zgbzrbbhhd44hqpkjosy2q