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Epigenetic and 3-dimensional regulation of V(D)J rearrangement of immunoglobulin genes
2010
Seminars in Immunology
V(D)J recombination is a crucial component of the adaptive immune response, allowing for the production of a diverse antigen receptor repertoire (Ig and TCR). This review will focus on how epigenetic regulation and 3-dimensional (3D) interactions may control V(D)J recombination at Ig loci. The interplay between transcription factors and post-translational modifications at the Igh, Igκ, and Igλ loci will be highlighted. Furthermore, we propose that the spatial organization and epigenetic
doi:10.1016/j.smim.2010.08.002
pmid:20833065
pmcid:PMC2981695
fatcat:oylatun3nrgmxnc24dpjrythvy