Epigenetic and 3-dimensional regulation of V(D)J rearrangement of immunoglobulin genes

Stephanie C. Degner-Leisso, Ann J. Feeney
2010 Seminars in Immunology  
V(D)J recombination is a crucial component of the adaptive immune response, allowing for the production of a diverse antigen receptor repertoire (Ig and TCR). This review will focus on how epigenetic regulation and 3-dimensional (3D) interactions may control V(D)J recombination at Ig loci. The interplay between transcription factors and post-translational modifications at the Igh, Igκ, and Igλ loci will be highlighted. Furthermore, we propose that the spatial organization and epigenetic
more » ... es of each Ig loci before and during V(D)J recombination may be influenced in part by the CTCF/cohesin complex. Taken together, the many epigenetic and 3-D layers of control ensure that Ig loci are only rearranged at appropriate stages of B-cell development.
doi:10.1016/j.smim.2010.08.002 pmid:20833065 pmcid:PMC2981695 fatcat:oylatun3nrgmxnc24dpjrythvy