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Microfluidic reactor array device for massively parallel in situ synthesis of oligonucleotides
2009
Sensors and actuators. B, Chemical
We have designed and fabricated a microfluidic reactor array device for massively parallel in-situ synthesis of oligonucleotides (oDNA). The device is made of glass anodically bonded to silicon consisting of three level features: microreactors, microchannels and through inlet/outlet holes. Main challenges in the design of this device include preventing diffusion of photogenerated reagents upon activation and achieving uniform reagent flow through thousands of parallel reactors. The device
doi:10.1016/j.snb.2009.04.071
pmid:20161215
pmcid:PMC2716077
fatcat:aet2wequn5gctlvdk7nvq5si6i