Role of HCN Channels in Regulation of Synaptic Plasticity at Early Postnatal Medial Perforant Path

Gulshat Badel
HCN channel blocker ZD7288 depressed synaptic transmission at medial perforant path (MPP) synapses. Low-frequency stimulation (LFS) delivered to these fibers resulted in enhanced LTD after ZD7288 in P9-15 rats, but not in P30-60 rats. Hence, HCN channel activation during neuronal activity may compromise the propensity of LTD at these synapses. Results obtained with L-NAME iterated the effect of HCN channel inhibition on LTD, suggesting that retrograde signaling with NO might play a major role
more » ... the linkage between postsynaptic NMDAR activation and presynaptic HCN channel function.
doi:10.18453/rosdok_id00001312 fatcat:ryh7sjksnveblhebhkrvhur5lq