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Impact of between-tissue differences on pan-cancer predictions of drug sensitivity
2021
PLoS Computational Biology
Increased availability of drug response and genomics data for many tumor cell lines has accelerated the development of pan-cancer prediction models of drug response. However, it is unclear how much between-tissue differences in drug response and molecular characteristics may contribute to pan-cancer predictions. Also unknown is whether the performance of pan-cancer models could vary by cancer type. Here, we built a series of pan-cancer models using two datasets containing 346 and 504 cell
doi:10.1371/journal.pcbi.1008720
pmid:33630864
fatcat:rxedf4bo7rdgrggkninwsts5l4