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Cytosolic Thioredoxin Peroxidase I and II Are Important Defenses of Yeast against Organic Hydroperoxide Insult
Journal of Biological Chemistry
The cytosolic thioredoxin peroxidase II (cTPxII/ Tsa2p) from Saccharomyces cerevisiae shares 86% identity with the relatively well characterized cytosolic thioredoxin peroxidase I (cTPxI/Tsa1p). In contrast to cTPxI protein, cTPxII is not abundant and is highly inducible by peroxides. Here, we describe a unique phenotype for ⌬cTPxII strain; these cells were highly sensitive to tert-butylhydroperoxide (TBHP) but presented resistance to H 2 O 2 in fermentative and respiratory conditions. Indoi:10.1074/jbc.m313773200 pmid:15210711 fatcat:kqj4tv63qna4ja73oka4sjfexu