SP780PREGNANCY AFTER KIDNEY TRANSPLANTATION : OUTCOMES, TACROLIMUS DOSES AND TROUGH LEVELS

Serkan Akturk, Zeynep Kendi Celebi, Siyar Erdogmus, Ahkam Goksel Kanmaz, Tuncay Yüce, Sule Sengul, Kenan Keven
2015 Nephrology, Dialysis and Transplantation  
Introduction and Aims: Although pregnancy after kidney transplantation has been considered as high risk for maternal and fetal complications, it can be successful in properly selected patients. It is well known that pregnancy can induce changes in the plasma concentrations of some drugs, however, there has been very limited information about tacrolimus pharmacokinetics during pregnancy. In this study, we evaluated the tacrolimus doses, blood level and the outcomes of pregnancies in kidney
more » ... aft recipients. Methods: Between 2004-2014, we found 16 pregnancies in 12 kidney allograft recipients in our center. We reviewed the files and data reports including fetal outcomes, graft function, complications, tacrolimus trough levels and the doses. We analysed the tacrolimus trough levels and doses before pregnancy, during pregnancy (monthly) and postpartum period. Results: Throughout the pregnancy, we aimed to achieve tacrolimus trough levels between 4-7 ng/ml. All patients were on triple immunosuppression including
doi:10.1093/ndt/gfv202.06 fatcat:xap2nxzl2fb2dm3x75a6ayesze