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Conopressin-T fromConus tulipaReveals an Antagonist Switch in Vasopressin-like Peptides
Journal of Biological Chemistry
We report the discovery of conopressin-T, a novel bioactive peptide isolated from Conus tulipa venom. Conopressin-T belongs to the vasopressin-like peptide family and displays high sequence homology to the mammalian hormone oxytocin (OT) and to vasotocin, the endogenous vasopressin analogue found in teleost fish, the cone snail's prey. Conopressin-T was found to act as a selective antagonist at the human V 1a receptor. All peptides in this family contain two conserved amino acids within thedoi:10.1074/jbc.m706477200 pmid:18174156 fatcat:lacam5thtbcg5ljbj7llvelfb4