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The Role of Trace Metals in Alzheimer's Disease [chapter]

Chiara A. De Benedictis, Cellular Neurobiology and Neuro-Nanotechnology Lab, Department of Biological Sciences, University of Limerick, Limerick, Ireland, Antonietta Vilella, Andreas M. Grabrucker, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy, Cellular Neurobiology and Neuro-Nanotechnology Lab, Department of Biological Sciences, University of Limerick, Limerick, Ireland, Bernal Institute, University of Limerick, Limerick, Ireland, Health Research Institute (HRI), University of Limerick, Limerick, Ireland
2019 Alzheimer's Disease  

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The extracellular aggregation of insoluble protein deposits of amyloid-β (Aβ) into plaques and the hyperphosphorylation of the intracellular protein tau leading to neurofibrillary tangles are the main pathological hallmarks of Alzheimer' s disease (AD). Both Aβ and tau are metal-binding proteins. Essential trace metals such as zinc, copper, and iron play important roles in healthy brain function but altered homeostasis and distribution have been linked to neurodegenerative diseases and aging.
more » ... addition, the presence of non-essential trace metals such as aluminum has been associated with AD. Trace metals and abnormal metal metabolism can influence protein aggregation, synaptic signaling pathways, mitochondrial function, oxidative stress levels, and inflammation, ultimately resulting in synapse dysfunction and neuronal loss in the AD brain. Herein we provide an overview of metals and metal-binding proteins and their pathophysiological role in AD.
doi:10.15586/alzheimersdisease.2019.ch6 fatcat:bpbzh3bq2jhq5njq4ttkzqvmh4
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Chiara A. De Benedictis, Cellular Neurobiology and Neuro-Nanotechnology Lab, Department of Biological Sciences, University of Limerick, Limerick, Ireland, Antonietta Vilella, Andreas M. Grabrucker, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy, Cellular Neurobiology and Neuro-Nanotechnology Lab, Department of Biological Sciences, University of Limerick, Limerick, Ireland, Bernal Institute, University of Limerick, Limerick, Ireland, Health Research Institute (HRI), University of Limerick, Limerick, Ireland. "The Role of Trace Metals in Alzheimer's Disease." Alzheimer's Disease (2019) 85-106