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Certified dOFM sampling devices provide access to target tissue in pharmaceutical trials
Clinical testing of dermatological drugs requires access to the site of drug action within the dermis. Conventional methods such as skin biopsies are rather invasive and provide limited data on the kinetics and dynamics of drugs. We present minimally invasive dermal sampling probes and a wearable pump for continuous sampling from the dermis. These dermal open flow microperfusion (dOFM) devices comply with international medical device guidelines (CE certified) and have demonstrated applicabilitydoi:10.1515/bmt-2013-4133 pmid:24042762 fatcat:6phigr5ifrg3bow6xz44iwzebi