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Depletion of CBP is directly linked with cellular toxicity caused by mutant huntingtin
2006
Neurobiology of Disease
Huntington's disease is a neurodegenerative disease caused by an expanded polyglutamine stretch within the huntingtin protein. Transfection of mutant huntingtin causes cell toxicity and depletion of CREB binding protein (CBP) or its recruitment into huntingtin aggregates. However, the role of CBP has been controversial and the relationship between polyglutamine-induced toxicity and CBP depletion has not been examined on an individual cell basis. Using a single-cell based assay, we found that,
doi:10.1016/j.nbd.2006.04.011
pmid:16766198
fatcat:wce77vn62beytfd6t5do6lvzem